Pharmaceutical Intermediate Material Characteristics

Pharmaceutical intermediates are actually some chemical raw materials or chemical products used in the drug synthesis process. This chemical product does not require a drug production license and can be produced in ordinary chemical plants. As long as it reaches a certain level, it can be used in the synthesis of drugs.

Pharmaceutical intermediate dryer equipment characteristics

Double-cone rotary vacuum dryer is a drying equipment that integrates mixing and vacuum drying. The process of vacuum drying is to place the dried material in a sealed cylinder, use a vacuum system to vacuum and continuously heat the dried material, so that the moisture inside the material can diffuse to the surface through pressure difference or concentration difference. Water molecules (or other non-condensable gases) gain enough kinetic energy on the surface of the material, overcome the mutual attraction between the molecules, and then diffuse into the low-pressure space of the vacuum chamber, and are pumped away by the vacuum pump to complete the separation from the solid. Therefore, the double-cone rotary vacuum dryer has the following characteristics:

(1) During the vacuum drying process, the pressure in the cylinder is always lower than the atmospheric pressure, and the number of gas molecules is small, the density is low, and the oxygen content is low, so it can dry easily oxidized drugs and reduce the chance of material contamination.

(2) Since the temperature of moisture is proportional to the steam pressure during the vaporization process, during vacuum drying, the moisture in the material can be vaporized at low temperatures to achieve low-temperature drying, which is especially suitable for the production of pharmaceuticals with heat-sensitive materials.

(3) Vacuum drying can eliminate the surface hardening phenomenon easily caused by atmospheric hot air drying. This is because the pressure difference between the inside and the surface of the vacuum dried material is large. Under the action of the pressure gradient, moisture quickly moves to the surface and no surface hardening occurs.

(4) During vacuum drying, the temperature gradient between the inside and outside of the material is small, and due to reverse osmosis, the moisture can move and collect alone, effectively overcoming the separation phenomenon caused by hot air drying.

Theory shows that the equipment also has the following characteristics:（1）The heating temperature is constant, the vacuum degree is increased, and the speed is accelerated;（2）The vacuum degree is constant, and the heating temperature is increased, and the speed is accelerated;（3）If the vacuum degree is increased and the heating temperature is increased, the rate is greatly accelerated.（4）Hot water or steam can be used as heating medium (steam pressure is 0.40-0.50Mpa);（5）The inner wall of the dryer adopts an arc transition to avoid sanitary dead spots and solvent condensation and condensation and dripping into a layer of material trays to pollute the flow.

Pharmaceutical intermediate double cone rotary vacuum dryeradvantages

The machine is simple to operate and convenient to enter and exit materials, which greatly reduces the labor intensity of workers, reduces environmental pollution caused by materials during the drying process, improves product quality, and complies with the requirements of the drug management specification "GMP".